Zytanix is manufactured by Zydus Cadila Healthcare. The active substance comprised in Zytanix is Metolazone, low ceiling quinazoline diuretic and sulfonamide derivative.
Indications:- edema associated with congestive heart failure, liver cirrhosis, renal diseases including the nephrotic syndrome, and states of diminished renal function.
- management of mild to moderate essential hypertension (alone or in combination with other antihypertensive drugs of a different class).
Zytanix also can be used as an alternative oral agent for management of hypercalciuria, nephrolithiasis, and nephrogenic diabetes insipidus (NDI).
MOA (mechanism of action):Metolazone belongs to carbonic anhydrase inhibitors and acts as an antihypertensive due to its potent saluretic and diuretic properties. It inhibits electrolytes and sodium reabsorption. By these actions, Metolazone makes the water existing in human blood leave the body as urine, instead of being reabsorbed into the bloodstream. With such excretion of unnecessary fluid, blood pressure starts lowering. Metolazone also has vasodilatory effect: it relaxes the muscles in the walls of blood vessels by retrieving the salt from them, thereby contributing to hypertension decrease as well.
DosageZytanix tablets should be swallowed whole and taken with a few sips of water.
Blood hypertension:
The dosage, as well as the course duration, must be determined by a doctor for each individual patient.
The average recommended dose varies from 2,5 to 5 mg once daily.
Edema:
The dosage, as well as the course duration, must be determined by a doctor for each individual patient.
The recommended starting dose varies from 5 to 10 mg once daily. If a loop diuretic is used concomitantly, the starting dose should not exceed 2,5 mg PO once daily.
If average recommended dose varies up to 20 mg daily.
Precautions:
The patients taking Zytanix should be observed for clinical signs of fluid and/or electrolyte imbalance during the treatment course.
Missing a doseIf you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose.
OverdoseIf an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.
StorageStore at room temperature between 20 and 25 degrees C and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.
The most common side effects associated with the use of Zytanix are:
Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.
ContraindicationsDo not take Zytanix if you are allergic to Metolazone or any other quinazoline diuretic.
Do not take Zytanix if you are allergic to any of the other ingredients comprised in Zytanix.
Do not combine Zytanix with the use of antidiuretics.
Do not take Zytanix if you have anuria, liver disease (hepatic coma or pre-coma), asthma, diabetes, gout, pancreatitis, hypercalcemia, hyperuricemia, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, systemic lupus erythematosus or kidney disease.
Do not consume alcohol while taking Zytanix as it may decrease an antidiuretic effect of the medication.
Do not take Zytanix if you are currently taking anti-inflammatory drugs for pain or swelling (aspirin, ibuprofen, naproxen, diclofenac), barbiturates for sleep or seizure control (secobarbital, pentobarbital, mephobarbital), heart medications (digoxin, dofetilide), antipsychotics (lithium), antidiabetics (chlorpropamide), high blood pressure medications (enalapril, perindopril, irbesartan), muscle relaxants (diazepam, lorazepam, clonazepam), urinary tract drugs (methenamine), other diuretics, steroid hormones (cortisone, hydrocortisone, and prednisone) or anticoagulants (warfarin).
It is recommended not to use Zytanix in patients under 18 years of age.
It is recommended not to use Zytanix in pregnant women unless considered absolutely necessary by your doctor.
It is strictly prohibited to breastfeed during the Zytanix treatment course.
Q: What is Zytanix used for?
A: Zytanix is an oral diuretic for the treatment of edema associated with heart failure, renal diseases, and diminished renal function conditions. These tablets also have antihypertensive properties and are used to manage elevated blood pressure (hypertension).
Q: Is Zytanix safe?
A: Zytanix is safe for adults and elderly patients as long as used for prescribed conditions and at prescribed doses.
Q: Can Zytanix be used in pregnant women?
A: It is recommended not to use Zytanix in pregnant women unless considered absolutely necessary by your doctor.
Furosemide
Lasix is a diuretic (water pill) used to treat pediatric and adult patients who suffer from fluid build-ups in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. This medication can also be used for the treatment of adult patients with high blood pressure (hypertension). Lasix helps prevent strokes, heart attacks, and kidney problems.
Propranolol
Inderal LA is indicated as maintenance therapy in the treatment of high blood pressure (hypertension),�angina pectoris, and idiopathic�hypertrophic subaortic stenosis. The medicine is also used for the prevention of migraine headaches. Inderal LA lowers blood pressure, which helps reduce the risk of strokes, heart attacks, and other cardiovascular problems. It is beneficial for patients 18 years of age and above.
Furosemide
Lasix is a potent medicine indicated for adults and pediatric patients to treat fluid build-up (edema) associated with congestive heart failure, cirrhosis of the liver, and renal disease, including nephrotic syndrome. The medicine is also used in adults for the treatment of high blood pressure (hypertension) alone or in combination with other antihypertensive agents.
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