Inderal LA is formulated to provide patients with a sustained release of Propranolol - an active ingredient contained in the medicine. Propranolol belongs to a group of medications called ‘beta blockers’. It is a non-selective beta-adrenergic receptor blocker used in the treatment or prevention of many disorders including hypertension (high blood pressure), angina pectoris (chest pain or discomfort), idiopathic hypertrophic subaortic stenosis (IHSS), migraine, etc.
Inderal LA helps maintain the condition of hypertensive patients by lowering persistently elevated blood pressure in the arteries. Long-term treatment with the medication helps reduce the risk for the occurrence of such cardiovascular problems as coronary artery disease, strokes, heart attack, heart failure, and abnormal heart rhythms. The drug should not be utilized when high blood pressure emergencies happen.
The preparation helps manage angina pectoris (also known as stable angina), a condition associated with sharp chest pain and difficulty breathing due to not sufficient blood flow to the heart muscle. It decreases the frequency of chest pain episodes by relaxing the coronary arteries and enhancing the heart's blood supply.
Inderal LA improves heart function in patients with idiopathic hypertrophic subaortic stenosis (IHSS), characterized by an obstruction of blood flow from the heart. It is also used for the prevention of recurrent moderate-to-severe migraine headaches and works by reducing their severity.Indications
High blood pressure (hypertension) maintenance therapy.
Angina pectoris management (except for of Variant angina).
Idiopathic hypertrophic subaortic stenosis (IHSS) treatment.
Migraine prophylaxis.Mechanism of action
Propranolol is a non-selective beta-adrenergic receptor blocker which works to decrease blood pressure, heart rates, contractility of the heart muscle and its oxygen demand. This active substance is a competitive antagonist which competes with specific beta-adrenergic receptor stimulating agents for binding to beta-1adrenergic receptors in the heart where it acts as an inhibitor of sympathetic stimulation.
The antihypertensive effect of Propranolol is reached through its three main actions: reduction in cardiac output, suppression of the amounts of renin released by the kidneys, and a decrease in tonic sympathetic nerve outflow from vasomotor centers in the brain.
In managing angina pectoris, the medicine generally lowers the oxygen requirement of the heart by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the heart's contraction strength and vigor.
The anti-migraine effect exerted by Propanolol is performed through the inhibition of vasodilation or arteriolar spasms over the cortex.Dosage
The recommended dose of Inderal LA varies according to the disease being treated and the condition of a patient. The drug may be taken with or without food. Must be swallowed whole and not chewed.
The following maximum daily doses of Inderal LA must not be exceeded:
Discontinue therapy if the satisfactory response in preventing migraines is not reached after 4-6 weeks of the drug administration. Patients on a long-term Inderal LA therapy should take regular liver and renal function tests.Missed dose
If you miss a dose of Inderal LA, you should take it as soon as possible. If it is the time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose to make up for a forgotten one. Do not exceed the doctor’s recommended dose.Overdose
If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately. Do not exceed the doctor’s recommended dose.Storage
Store at room temperature below 30°C (80°F) away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of sight and reach of children.
The most common side effects associated with Inderal LA are:
Side effects occurrence does not only depend on the medication you are taking but also on your overall health and other factors.Contraindications
Do not take Inderal LA if:
Talk to your doctor before taking the preparation if you have liver or kidney problems.
Use Inderal LA with caution when driving or operating machinery as the medication may cause excessive tiredness and/or dizziness.
Avoid alcohol consumption while on Inderal LA tablets.
The medication is not recommended for use in children and adolescents under 18 years of age.Drug interactions
Avoid the co-administration of Inderal LA with the following medicinal products:
Q: What is Inderal LA and what to use it for?
A: Inderal LA is a beta-adrenergic blocker used for the treatment of high blood pressure, angina pectoris, hypertrophic subaortic stenosis, and the prevention of migraine headaches.
Q: How should I use the preparation?
A: Inderal LA is indicated for the oral administration once a day, regardless of food. Must be swallowed whole without chewing.
Q: Is it safe to take the medication if I’m pregnant or breastfeeding?
A: Inderal LA is not recommended for use in pregnant or breastfeeding women unless absolutely necessary. Please consult your doctor before taking the medicine.
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