What Zestoretic is and what it is used for
Zestoretic is an antihypertensive medication containing two medicines called Hydrochlorothiazide
and Lisinopril that work together to lower your blood pressure (hypertension).
Hydrochlorothiazide is a diuretic, which helps your body to get rid of water and
salts like sodium in your urine. Lisinopril belongs to a group of medicines called ACE inhibitors.
It works by making your blood vessels widen.
How to take Zestoretic
Always take this medication exactly as your doctor has told you. Once you have started taking
the drug, your doctor may take blood tests and then adjust your dose, so you take the right amount
of medicine for you.
Swallow the tablet whole with a drink of water.
Try to take your tablets at the same time each day. You may take the medication before or after
Keep taking this medication for as long as your doctor tells you to.
It is important to keep taking your pills every day.
If you take more pills than you should
If you take more than prescribed by your doctor, talk to a doctor, or go to a hospital
immediately. Take the medicine pack with you so that the tablets can be identified.
If you forget to take your pills
If you forget to take a dose, take it as soon as you remember. However, if it is nearly time for
the next dose, skip the missed one. Do not take a double dose to make up for a forgotten dose.
If you stop taking drug
Do not stop taking your tablets, even if you are feeling well unless your doctor tells you to.
How to store Zestoretic
Keep out of sight and reach of children. Store below 30°C (86°F). Protect your tablets from light
and moisture. Throw away any unused medicine after the expiration date.
Get emergency medical help if you have signs of an allergic reaction to the drug:
- severe stomach pain
- difficulty breathing
- swelling of your face, lips, tongue, or throat
Call your doctor at once if you have:
- a light-headed feeling, like you might pass out
- eye pain, vision problems
- little or no urination
- weakness, drowsiness, or feeling restless
- fever, chills, sore throat, mouth sores, trouble swallowing
- jaundice (yellowing of the skin or eyes)
- tingly feeling
- chest pain
- irregular heartbeats
- loss of movement
- leg cramps
- irregular heartbeats
- fluttering in your chest
- extreme thirst
- increased urination
- numbness or tingling
- muscle weakness or limp feeling
- confusion, slurred speech
Common drug side effects may include:
- tired feeling
If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible
side effects not listed above.
What you need to know before you take Zestoretic
Do not take this medication:
- If you are allergic to Hydrochlorothiazide or Lisinopril or any of the other ingredients
of the medication.
- If you are allergic to ACE inhibitor or sulphonamide medicines. If you are not sure if
this applies to you, please ask your doctor.
- If you have ever had sudden swelling of the hands, feet, ankles, face, lips, tongue or
throat, especially if this followed cure with an ACE inhibitor. It may also have been
difficult to swallow or breathe.
- If you have hereditary angioedema (a condition that makes you more prone to the swelling
described above). If you are not sure if this applies to you, please ask your doctor.
- If you have severe problems.
- If you have stopped passing water (urine).
- If you have severe liver problems.
- If you are more than 3 months pregnant. (It is also better to avoid drug in early
- If you have diabetes or impaired kidney function and you are treated with a blood pressure
lowering medicine containing aliskiren.
Do not take drug if any of the above applies to you. If you are not sure, talk to your
doctor or pharmacist before taking Zestoretic.
Warnings and precautions
Talk to your doctor or pharmacist before taking Zestoretic:
- If you have had skin cancer or if you develop an unexpected skin lesion during the
treatment. Cure with Hydrochlorothiazide, particularly long term use with high doses,
may increase the risk of some types of skin and lip cancer (non-melanoma skin cancer).
Protect your skin from sun exposure and UV rays while taking Zestoretic.
- If you have a narrowing (stenosis) of the aorta.
- If you have an increase in the thickness of the heart muscle (known as hypertrophic
- If you have problems with your blood vessels (collagen vascular disease).
- If you have low blood pressure. You may notice this as feeling dizzy or light-headed,
especially when standing up.
- If you have kidney problems or you are having dialysis, or you have had a kidney
- If you have liver problems.
- If you have diabetes.
- If you have recently had diarrhea or vomiting (being sick).
- If your doctor has told you to control the amount of salt in your diet.
- If you have high levels of cholesterol and you are having a treatment called ‘LDL
- If you have ever had a condition called systemic lupus erythematosus (SLE).
- If you are of black origin as Zestoretic may be less effective. You may also more readily
get the side effect ‘angioedema’ (a severe allergic reaction with swelling of the hands,
feet, ankles, face, lips, tongue or throat).
Other medicines and Zestoretic
Tell your doctor or pharmacist if you are taking any of the following medicines:
- Other antihypertensives
- An angiotensin II receptor blocker (ARB) or aliskiren
- Other “water tablets”, laxatives, corticosteroids (e.g., prednisone), ACTH (A hormone),
amphotericin (an antifungal medicine) and salicylic acid derivatives
- NSAIDs such as aspirin, ibuprofen or indomethacin
- Tricyclic and tetracyclic antidepressants
- Medicines for mental problems such as lithium
- Aspirin (acetylsalicylic acid) (if you are taking more than 3 grams each day)
- Potassium supplements, salt substitutes containing potassium
- Heparin (a medicine for thinning the blood)
- Co-trimoxazole (an antibiotic medicine) (known as trimethoprim-sulfamethoxazole).
- Calcium salts or Vitamin D supplements
- Oral antidiabetics such as sulphonylureas
- Medicines to treat asthma
- Immunosuppressants, such as ciclosporin)
- Allopurinol (for gout)
- Medicines for uneven heartbeat problems (such as procainamide)
- The medicines (e.g., digoxin) or other medicines to control the rhythm
- Corticosteroids (steroid medicines)
This is not an exhaustive list of possible drug interactions. Please consult your doctor about all
the possible interactions of the medicines you are taking.
Q: What is Zestoretic indicated for?
A: Zestoretic is used to treat hypertension (high blood pressure). The use of this medication
lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial
Q: Can I take this medication during pregnancy?
A: Zestoretic is not recommended in early pregnancy, and must not be taken when more than 3
months pregnant, as it may cause serious harm to your baby if used after the 3rd month of pregnancy.
Q: Is it safe to breastfeed a baby while on Zestoretic tablets?
A: Zestoretic is not recommended for mothers who are breastfeeding, and your doctor may choose
another treatment for you if you wish to breastfeed, especially if your baby is a newborn, or was
International Registered Mail - 21-30 business days, Price - $16.00, No signature is required upon delivery
EMS (Express Mail Service) - 14-21 business days, Price - $25.00, Signature may be required upon delivery
We will carefully pack your order to make sure it's safe and secure and will dispatch it within 24 hours.
For your privacy we package all parcels to look like regular private mail. We will not disclose the contents of your order. Package dimensions: 9.4x4.3x0.3 inches (24x11x0.7cm).