Demadex is a diuretic medication that is used to reduce the amount of water in the body in such conditions as congestive heart failure, liver disease, or kidney disease. It helps the kidneys to increase the flow of urine. The medication is also used to lower high blood pressure alone or in combination with other antihypertensive agents. Torsemide is an active ingredient of Demadex. It is a loop diuretic (‘water pill’) which prevents the body from absorbing too much salt. It works primarily on the kidneys and removes excess water and certain electrolytes from the body through the urine.Indications
Treatment of hypertension (high blood pressure).
Treatment of edema (fluid retention).Mechanism of action
Torsemide is a pyridine-sulfonylurea type loop diuretic which selectively blocks active sodium and chloride reabsorption in the thick ascending loop of Henle, promoting rapid excretion of the water, sodium, and chloride. This action is a result of binding of the diuretic to a chloride ion binding site of the transport molecule. Torsemide also lowers systolic and diastolic blood pressure in patients with acute heart failure or chronic renal failure. Torsemide reduces both preload and afterload in patients with heart failure.Dosage
Demadex comes in the form of a tablet and is usually administered once daily. The medicine may be taken with or without food. Because Torsemide increases urination, it is recommended to take the medication in the morning to avoid having to get up in the night to urinate.
The maximum adult dose of Demadex is as follows:
If you miss a dose of Demadex, you should take it as soon as possible. If it is the time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose to make up for a forgotten one. Do not exceed the doctor’s recommended dose.Overdose
If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately. Do not exceed the doctor’s recommended dose.Storage
Store at room temperature between 15° and 30°C (59° to 86°F) away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of sight and reach of children.
The most common side effects associated with Demadex are:
Side effects occurrence does not only depend on the medication you are taking but also on your overall health and other factors.Contraindications
Do not take this drug if you are allergic to the active ingredient Torsemide, the drug’s excipients, or any other sulfa medications.
Do not use Demadex if you have anuria (a condition in which the kidneys are unable to produce urine).
Do not take this medicine if you have liver problems such as cirrhosis or hepatitis.
Do not take this medication in case you have severe heart disease.
Do not take this drug if you are prone to hypokalemia as the medicine may cause a loss of potassium from the body.
Do not use the medication during pregnancy or when breastfeeding without your doctor’s advice.
The medicine is not for use in patients under 18 years of age.
It is not recommended to take Demadex if you are on a low-salt diet.Drug interactions
Do not co-administrate Demadex with any of the following preparations:
Q: What is Demadex used for?
A: The medication is used in the treatment of adults with high blood pressure (hypertension), and fluid retention (edema) caused by congestive heart failure, liver or kidney diseases.
Q: How should I take the medicine?
A: Demadex is for a once-daily administration. You may take medicine with or without food. It is recommended to take the medication in the morning since Torsemide increases urination.
Q: Can I use the drug during pregnancy or when breastfeeding?
A: The medication is not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the possible risks. Do not take any medicines without talking to your doctor first.
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